For Week 2 of the Midwest Appeal NCAA FBS, we have five inter-region matchups marked in red …
| Sept. 9 | Akron Zips | Arkansas-Pine Bluff Golden Lions |
| Ball State Cardinals | UAB Blazers | |
| Bowling Green Falcons | South Dakota Coyotes | |
| Eastern Michigan Eagles | at Rutgers Scarlet Knights | |
| Illinois Fighting Illini | Western Kentucky Hilltoppers | |
| Indiana Hoosiers | at Virginia Cavaliers | |
| Iowa State Cyclones | Iowa Hawkeyes | |
| Kansas Jayhawks | Central Michigan Chippewas | |
| No. 19/19 Kansas State Wildcats | Charlotte 49ers | |
| Kent State Golden Flashes | Howard Bison | |
| Miami Ohio Redhawks | Austin Peay Governors | |
| No. 8/8 Michigan Wolverines | Cincinnati Bearcats | |
| Michigan State Spartans | Western Michigan Broncos | |
| Minnesota Golden Gophers | at Oregon State Beavers | |
| Missouri Tigers | South Carolina Gamecocks | |
| Nebraska Cornhuskers | at Oregon Ducks | |
| Northern Illinois Huskies | Eastern Illinois Panthers | |
| Northwestern Wildcats | at Duke Blue Devils | |
| No. 24/25 Notre Dame Fighting Irish | No. 15/15 Georgia Bulldogs | |
| No. 2/2 Ohio State Buckeyes | No. 5/6 Oklahoma Sooners | |
| Toledo Rockets | at Nevada Wolf Pack | |
| No. 9/11 Wisconsin Badgers | Florida Atlantic Owls |
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